*denotes equal contribution †denotes co-corresponding authors

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism.
Prakash P†, Limberg KC*, Zhang W*, Zhao Y, Laborc KF, O'Keeffe A, Vilnaigre BC, Appleby H, O'Dea MR, Fernandez-Cerado C, Legarda GPA, Sy M, Muñoz EL, Ang MAC, Diesta CCE, Han J, Norenberg E, Penney EB, Bragg DC, Mar AC, Brosh R, Boeke JD, Liddelow SA†.
bioRxiv [Preprint]. 2025 Oct 8:2025.10.07.680990.
doi: 10.1101/2025.10.07.680990. PMID: 41278988; PMCID: PMC12632464.

• Research highlighted in NPR’s All Things Considered: Once dismissed, these cells in the brain have the spotlight in the neuroscience world
  

Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism.
Zhang W, Zhao Y*, Prakash P*, Appleby HL, Barriball K, Capponi S, Jiang Q, Wudzinska AM, Vaine CA, Ellis G, Rahman N, Markovic S, Mishkit O, Limberg KC, Maurano MT, Wadghiri YZ, Kim SY, Timmers HTM, Bragg DC, Liddelow SA, Brosh R, Boeke JD.
bioRxiv [Preprint]. 2025 Oct 8:2025.10.07.680816.
doi: 10.1101/2025.10.07.680816. PMID: 41279153; PMCID: PMC12632633.


Advances in the genetics and pathology of Lewy body dementia.
Scholz SW, Okubadejo NU, Prakash P, Liddelow SA, Ryten M, Halliday GM.
Lancet Neurol. 2025 Dec;24(12):1026-1037.
doi: 10.1016/S1474-4422(25)00363-1. PMID: 41240918.


Single-cell analysis of the nervous system at small and large scales with instant partitions.
Frazel PW, Fricano-Kugler K, May-Zhang AA, O'Dea MR, Prakash P, Desmet NM, Lee H, Meltzer RH, Fontanez KM, Hettige P, Agam Y, Lithwick-Yanai G, Lipson D, Luikart BW, Dasen JD, Liddelow SA.
bioRxiv [Preprint]. 2023 Jul 18:2023.07.14.549051.
doi: 10.1101/2023.07.14.549051. PMID: 37503160; PMCID: PMC10370061.


Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human.
Prakash P†, Erdjument-Bromage H, O'Dea MR, Munson CN, Labib D, Fossati V, Neubert TA, Liddelow SA†.
Glia. 2024 Mar;72(3):625-642.
doi: 10.1002/glia.24494. Epub 2023 Nov 30. PMID: 38031883; PMCID: PMC10843807.

• NYSCF News: How the ‘Stars of the Brain’ Could Protect Us From Neurodegeneration

• Top viewed article in Glia among work published in Glia between Jan 1st to Dec 31st, 2023, up to 12 months after publication

Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models.
Labib D, Wang Z, Prakash P, Zimmer M, Smith MD, Frazel PW, Barbar L, Sapar ML, Calabresi PA, Peng J, Liddelow SA, Fossati V.
Front Mol Neurosci. 2022 May 3;15:870085.
doi: 10.3389/fnmol.2022.870085. PMID: 35592112; PMCID: PMC9113221.


Lipids: Emerging Players of Microglial Biology.
Prakash P†, Randolph CE, Walker KA, Chopra G†.
Glia. 2025 Mar;73(3):657-677.
doi: 10.1002/glia.24654. Epub 2024 Dec 17. PMID: 39688320; PMCID: PMC11784843.


Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease.
Prakash P*, Manchanda P*, Paouri E, Bisht K, Sharma K, Rajpoot J, Wendt V, Hossain A, Wijewardhane PR, Randolph CE, Chen Y, Stanko S, Gasmi N, Gjojdeshi A, Card S, Fine J, Jethava KP, Clark MG, Dong B, Ma S, Crockett A, Thayer EA, Nicolas M, Davis R, Hardikar D, Allende D, Prayson RA, Zhang C, Davalos D, Chopra G.
Immunity. 2025 Jun 10;58(6):1536-1552.e8.
doi: 10.1016/j.immuni.2025.04.029. Epub 2025 May 19. PMID: 40393454; PMCID: PMC12168635.

• Science Alert: Fat Buildup in Brain Cells Could Provide New Target For Alzheimer's Treatment

• Alzforum News: Lipid-Laden, Sluggish Microglia? Blame Aβ

• The Hindu newspaper: Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques

• The Scientist: Amyloid Beta Impairs Microglia Function in Alzheimer’s Disease

• Purdue News: Purdue-led study shows how fat disables the brain’s immune shield in Alzheimer’s disease 

One Scaffold, Different Organelle Sensors: pH-Activable Fluorescent Probes for Targeting Live Microglial Cell Organelles.
Jethava KP*, Prakash P*, Manchanda P, Arora H, Chopra G.
Chembiochem. 2022 May 4;23(9):e202100378.
doi: 10.1002/cbic.202100378. Epub 2021 Oct 13. PMID: 34585478; PMCID: PMC9835645.

• Selected for Front Cover Feature, Issue 9, Vol 23, 2022
  
  

Neurotoxic reactive astrocytes induce cell death via saturated lipids.
Guttenplan KA, Weigel MK*, Prakash P*, Wijewardhane PR, Hasel P, Rufen-Blanchette U, Münch AE, Blum JA, Fine J, Neal MC, Bruce KD, Gitler AD, Chopra G, Liddelow SA, Barres BA.
Nature. 2021 Nov;599(7883):102-107.
doi: 10.1038/s41586-021-03960-y. Epub 2021 Oct 6. PMID: 34616039; PMCID: PMC12054010.

• Alzforum News: ELOVL Hurts—Enzyme Makes Lipids That Turn Astrocytes Toxic

• NYU Health News: Toxic Fatty Acids to Blame for Brain Cell Death After Initial Injury

• Genetic Engineering & Biotechnology News: Toxic Fatty Acids Could Represent New Targetfor Treating Neurodegenerative Disorders

• Times Now News: Cure for dementia and Parkinson's in sight? Scientists find cells that cause neurological diseases

Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time.
Prakash P*, Jethava KP*, Korte N*, Izquierdo P*, Favuzzi E, Rose IVL, Guttenplan KA, Manchanda P, Dutta S, Rochet JC, Fishell G, Liddelow SA, Attwell D, Chopra G.
Chem Sci. 2021 Jul 21;12(32):10901-10918.
doi: 10.1039/d1sc03486c. PMID: 34476070; PMCID: PMC8372545.


Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid beta 1-42.
Prakash P*, Lantz TC*, Jethava KP, Chopra G.
Methods Protoc. 2019 Jun 7;2(2):48.
doi: 10.3390/mps2020048. PMID: 31181684; PMCID: PMC6632169.

Proposed cover (unpublished).
Art by drawimpacts.